翻訳と辞書 Words near each other ・ Phosphohydroxypyruvic acid ・ Phosphoinositide 3-kinase ・ Phosphoinositide 3-kinase inhibitor ・ Phosphoinositide 5-phosphatase ・ Phosphoinositide phospholipase C ・ Phosphoinositide-dependent kinase-1 ・ Phosphoketolase ・ Phospholamban ・ Phosphole ・ Phospholipase ・ Phospholipase A ・ Phospholipase A1 ・ Phospholipase A2 ・ Phospholipase B ・ Phospholipase C ・ Phospholipase D ・ Phospholipase D1 ・ Phospholipid ・ Phospholipid acyltransferase ・ Phospholipid scramblase ・ Phospholipid transfer protein ・ Phospholipid-derived fatty acids ・ Phospholipid-hydroperoxide glutathione peroxidase ・ Phospholipid-translocating ATPase ・ Phospholipidosis ・ Phosphomannan mannosephosphotransferase ・ Phosphomannomutase ・ Phosphomethylpyrimidine kinase ・ Phosphomethylpyrimidine synthase ・ Phosphomevalonate kinase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phospholipase D ： ウィキペディア英語版 Phospholipase D Phospholipase D (, ''lipophosphodiesterase II'', ''lecithinase D'', ''choline phosphatase'') (PLD) is an enzyme of the phospholipase superfamily. Phospholipases are widely occurring, and can be found in a wide range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase D’s principal substrate is phosphatidylcholine, which it hydrolyzes to produce the signal molecule phosphatidic acid (PA), and soluble choline. Plants contain numerous genes that encode various PLD isoenzymes, with molecular weights ranging from 90-125 kDa. Mammalian cells encode two isoforms of phospholipase D: PLD1 and PLD2. Phospholipase D is an important player in many physiological processes, including membrane trafficking, cytoskeletal reorganization, receptor-mediated endocytosis, exocytosis, and cell migration. Through these processes, it has been further implicated in the pathophysiology of multiple diseases: in particular the progression of Parkinson’s and Alzheimer’s, as well as various cancers.〔 == Discovery == PLD-type activity was first reported in 1947 by Donald J. Hanahan and I.L. Chaikoff. It was not until 1975, however, that the hydrolytic mechanism of action was elucidated in mammalian cells. Plant isoforms of PLD were first purified from cabbage and castor bean; PLDα was ultimately cloned and characterized from a variety of plants, including rice, corn, and tomato. Plant PLDs have been cloned in three isoforms: PLDα, PLDβ, and PLDγ. More than half a century of biochemical studies have implicated phospholipase D and PA activity in a wide range of physiological processes and diseases, including inflammation, diabetes, phagocytosis, neuronal & cardiac signaling, and oncogenesis. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phospholipase D」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.